Belotero®
Belotero® ((Belotero®) is a product under Merz Aesthetics Cross-linked hyaluronic acid (HA) gel filler family, originally developed by Swiss company…
Real Belotero® Filler Treatment Cases at Our Nanjing Clinic
The following are clinical injection records performed personally by our physician at our Nanjing clinic. All Before & After images are unretouched clinical photographs; all clients have signed a written Media Release Form. Belotero’s CPM monophasic polydensified gel excels at ultra-superficial intradermal injection — delivering uniquely consistent results in areas where other HAs commonly cause Tyndall blue discoloration, including periorbital fine lines, perioral vertical lines, smoker’s lines, and the superficial tear trough layer. Actual outcomes vary by product line (Soft / Balance / Intense / Volume / Revive) · Results vary depending on injection depth, anatomical structure, and individual metabolic rate.
Case 1 · Belotero® Real Clinical Record
- Ideal Candidate Profile
- Asian Female · Fitzpatrick IV · Results Lasting ~1–2 Years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 1: Asian Female · Fitzpatrick IV · Visible results lasting approximately 1–2 years · Belotero® as the core component of a comprehensive tear trough treatment plan (multiple sessions within 3 months) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 2 · Belotero® Filler — Real Treatment Record
- Ideal Candidate Profile
- Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 2: Asian Male · Fitzpatrick IV · Results Lasting ~1–2 Years · Belotero® as a core component of a comprehensive tear trough treatment plan (within 3 months × multiple sessions) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 3 · Belotero® Real Patient Results
- Ideal Candidate Profile
- Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 3: Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years · Belotero® as the core component of a comprehensive tear trough correction plan (multiple sessions within 3 months) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 4 · Belotero® Real Clinical Record
- Ideal Candidate Profile
- Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 4: Asian male · Fitzpatrick IV · Visible concern for approximately 1–2 years · Belotero® as the central component of a comprehensive tear trough treatment plan (multiple sessions within 3 months) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 5 · Belotero® Filler — Real Treatment Record
- Ideal Candidate Profile
- Asian Female · Fitzpatrick IV · Results Lasting ~1–2 Years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 5: Asian Female · Fitzpatrick IV · Visible results lasting approximately 1–2 years · Belotero® as the core component of a comprehensive tear trough treatment plan (multiple sessions within 3 months) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 6 · Belotero® Real Patient Results
- Ideal Candidate Profile
- Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 6: Asian Male · Fitzpatrick IV · Results Lasting ~1–2 Years · Belotero® as a core component of a comprehensive tear trough treatment plan (within 3 months × multiple sessions) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 7 · Belotero® Real Patient Record
- Ideal Candidate Profile
- Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Belotero® HA filler (multiple sessions within 3 months)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- 10-14 months later for a top-up · Supplementary skin booster sessions in between
Case 7: Asian male · Fitzpatrick IV · Concerns present for approximately 1–2 years · Belotero® as the core component of a comprehensive tear trough correction plan (multiple sessions within 3 months) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Case 8 · Belotero® Real Clinical Record
- Ideal Candidate Profile
- Asian Female · Fitzpatrick IV · Results Lasting ~1–2 Years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- Pico® Skin brightening & rejuvenation + PicoSure® + PicoSure Pro® + PicoWay® and 12 additional treatments (within 3 months × multiple sessions)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- Daily sun protection + monthly home care routine + quarterly clinic assessments
Case 8: Asian Female · Fitzpatrick IV · Results Lasting ~1–2 Years · Belotero® as a core component of a comprehensive treatment plan addressing tear troughs, hyperpigmentation, age spots, facial laxity/jowling, dull complexion & fatigue appearance, upper eyelid ptosis, under-eye bags & dark circles, volume loss, Luowei skeletal facial contouring, forehead hollowing, uneven skin tone (within 3 months × multiple sessions) · Performed by our physician at Luowei Medical Aesthetics Clinic, Nanjing led in Nanjing
Case 9 · Belotero® Filler — Real Treatment Record
- Ideal Candidate Profile
- Asian female · Fitzpatrick I · Concern present for approximately 2–3 years
- Concerns
- Belotero® HA filler (multimodal combination therapy for comprehensive improvement)
- Treatment plan
- PicoSure® + IPL Photofacial (within 3 months × multiple sessions)
- Treatment results
- Belotero® Meaningful improvement with HA filler · Overall result appears natural
- Post-inflammatory hyperpigmentation (PIH) risk
- No PIH
- Maintenance
- Daily sun protection + monthly home care routine + quarterly clinic assessments
Case 9: Asian Female · Fitzpatrick I · Results lasting approximately 2–3 years · Belotero® as the core component of a comprehensive treatment plan addressing under-eye bags & dark circles, facial sagging / jowling, upper eyelid ptosis, tear trough, lip augmentation, thin lips, lip reshaping, pout lips, smile lips, temple hollowing, and forehead hollowing (multiple sessions within 3 months) · Led by our physician at Luowei Medical Aesthetics Clinic, Nanjing
Why Choose Luowei Medical Aesthetics Clinic for Belotero® Filler in Nanjing
The filler defines the possibilities; the physician defines the outcome. Belotero CPM is the only HA filler that can be placed into the most superficial dermal plane without producing Tyndall-effect bluing — but this requires a physician who can precisely identify which fine lines, anatomical structures, and tissue depths are appropriate for CPM monophasic gel.
Merz Aesthetics Authorized Provider
Belotero® Originally developed by Swiss company Anteis SA, Belotero® is now part of the German Merz Aesthetics group — the same group behind Radiesse® and Xeomin®. Luowei Medical Aesthetics Clinic is an authorized Merz Aesthetics partner clinic in China. All Belotero products are sourced directly through Merz’s domestic distribution network with fully traceable cold-chain logistics. Our physician regularly participates in Merz international aesthetic conferences and CPM technique training.
CPM Expertise in most superficial dermal injection
Belotero CPM The gel can be injected into Sub-epidermal layer / papillary dermis— This is a depth that neither Juvéderm® Vycross nor Restylane® NASHA technology can achieve. Our physician has Perioral barcode lines“He has accumulated extensive CPM application experience in periorbital fine lines, perioral (smoker’s) lines, and superficial tear trough correction — areas where truly invisible results are the goal” seamless filling “areas including superficial periorbital fine lines, smoker’s lines, and shallow tear trough correction.
Belotero Full product line available
Clinic Equipment Belotero Soft / Balance / Intense / Volume / Revive The complete 5-product line spans a full density gradient from ultra-superficial dermis (Soft) to deep periosteal support (Volume). Our physician selects the most appropriate product based on your wrinkle depth, skin thickness, and dynamic requirements — combining multiple products in layered application when clinically indicated.
Hyaluronidase emergency protocol
Available on-site at all times Hylenex (hyaluronidase) Hyaluronidase, In the critical 4-hour window following rare but serious complications such as vascular occlusion, Belotero® can be promptly dissolved to restore blood flow. The single-phase gel structure of Belotero responds readily to Hylenex, enabling efficient and reliable dissolution — another key clinical advantage of CPM technology.
- NMPA-registered (Belotero Balance for nasolabial folds) · NMPA-registered— Belotero® The only NMPA-registered HA filler indicated for ultra-superficial intradermal injection
- Merz Aesthetics Authorized Provider— All Belotero products are sourced directly through Chinese domestic distribution channels with full cold-chain traceability
- Ability to combine multiple HA brands in one treatment plan— Belotero / Juvéderm/ Restylane/ Teosyal All available at the same clinic
- Hylenex Hyaluronidase emergency kit on site at all times— Vascular occlusion emergency response within the 4-hour critical window
Belotero® What is Belotero® dermal filler?
Belotero® ((Belotero®) is a product under Merz Aesthetics Cross-linked hyaluronic acid (HA) gel filler family, originally developed by Swiss company Anteis SA,Formulated with proprietary CPM (Cohesive Polydensified Matrix) monophasic cross-linking technology our clinical expertise on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. FDA Belotero Balance was approved in 2011 for the treatment of moderate-to-severe nasolabial folds, making it The only filler NMPA-registered for injection into the ultra-superficial dermis (subepidermal / papillary dermis) without producing the Tyndall blue-gray effect HA filler. Note: hyaluronic acid is dermal filler, and Botox® Botulinum toxin These treatments serve entirely different functions — neuromodulators (e.g., Botox®) relax muscles, while HA fillers restore volume and contour.
Belotero CPM Once the gel is delivered into the subcutaneous tissue or dermis,Creates a continuous density-gradient transition + hydrates by attracting water + stimulates collagen regeneration Triple action. Hyaluronic acid is a naturally occurring glycosaminoglycan (GAG) found in the dermis, joints, and eyes. One gram of HA can bind up to 1,000 mL of water, making it the key molecule behind skin hydration and volume.
Belotero The key differentiator from other HA brands lies in CPM Monophasic polydensified cross-linking technology: “Traditional biphasic HA (such as Restylane® NASHA particle-type) consists of particles suspended in liquid; when injected superficially, the difference in refractive index can cause a Tyndall blue-gray discoloration. CPM technology addresses this by The first cross-linking step establishes a low-density network; the second cross-linking step layers a high-density cross-link over the existing network, formation A single continuous gel with controllable density distribution— The entire gel has a uniform refractive index, producing no light scattering when placed superficially, allowing for a natural skin tone transition,With seamless integration into surrounding tissue (tissue integration), The texture is virtually indistinguishable from surrounding native tissue.
Belotero Product Line Technical Specifications
- Active ingredient Cross-linked hyaluronic acid (HA) gel · Select products contain 0.3% lidocaine (Lidocaine series)
- Cross-linking technology CPM (Cohesive Polydensified Matrix) Monophasic polydensified dual cross-linking
- Mechanism of action Gradient-density filling + seamless tissue integration + hydration + collagen stimulation
- Onset of results Immediate visible results · Final result stabilises at 14 days (once swelling has fully resolved)
- Duration of results Soft 6-9 months · Balance 6–12 months · Intense / Volume 12 months
- NMPA-registered 2011 (Belotero Balance nasolabial folds) · NMPA-registered for the full product line
- Unique advantages The only HA filler that can be injected into the ultra-superficial dermis without producing Tyndall blue discoloration
- Volume per syringe 1 ml (Soft / Balance / Intense / Revive) · 2 ml (Volume)
- Manufacturer Merz Aesthetics (Germany) · Originally developed by Anteis SA, Switzerland
Belotero vs Comparison with Other HA Filler Brands
| Brand | Cross-linking technology | G’ Elasticity | Tyndall Risks |
|---|---|---|---|
| Belotero® | CPM Monophasic multi-density | Low-to-medium (controllable density gradient) | Extremely low (injectable into ultra-superficial layers) |
| Juvéderm® | Vycross / Hylacross | Medium-high (Volux is the firmest) | Medium (not recommended for subepidermal placement) |
| Restylane® | NASHA / OBT (XpresHAn) | High (Lyft strongest) | Medium-high (particle refraction) |
| Teosyal® | Preserved Network | Medium | Medium |
Note: Belotero’s CPM monophasic gel has a uniform refractive index that closely matches the optical properties of skin tissue — this is the physical basis for its absence of Tyndall blue discolouration when used superficially in the tear trough, periorbital, and perioral areas.
Belotero® How Belotero® Filler Works
Belotero CPM The monophasic gel is precisely injected into the target anatomical plane — most superficial dermis / mid-dermis / deep dermis / supraperiosteal — to create Volumetric support with continuous density gradient transition, The gel integrates seamlessly with surrounding tissue, absorbs moisture to provide volume and hydration, and mechanically stimulates fibroblasts to produce new collagen. The ability to inject CPM monophasic gel at a superficial plane is Belotero’s core differentiator.
Consultation & Anatomical Assessment
Our physician assesses your superficial fine line distribution, skin laxity, and prior filler history using MD Codes anatomical analysis, caliper-measured dermal thickness, and fine line depth grading via the Glogau Photoaging Classification and Lemperle Wrinkle Scale. The primary characteristics that make a patient a strong candidate for Belotero are Dense superficial fine lines, thinner skin, seeking a seamless, trace-free result— This is an entirely different set of indications from deep volumizers such as Voluma.
Product Selection & Dosage Calculation
Based on wrinkle depth and treatment area, our physician selects the appropriate Belotero® product:Very superficial fine lines (periorbital / perioral / smoker’s lines / vertical lines) → Soft (Lowest density, 0.5–1.5 mm subdermal depth)Moderate depth (nasolabial folds / corner lines / vermilion border) → Balance (CPM Classic formulation, NMPA-registered)Deep wrinkles + lips → Intense (Medium density, 2–3 mm subcutaneous depth)Deep structural support (zygomatic area / jawline / nasal base) → Volume (Highest density, supraperiosteal)Skin hydration and radiance → Revive ((glycine + proline Skinbooster).
Anatomical Mapping & Vascular Avoidance
Following skin disinfection, each injection point and vascular danger zone is precisely marked with a medical-grade skin marker. Particular care is taken to avoid Facial artery, angular artery, supratrochlear artery, infraorbital artery and other key vessels. Belotero Volume deep-layer volumizing prioritizes the use of 27 G Blunt cannula technique; superficial injections of Belotero® Soft / Balance are typically performed using 30-32 G Sharp needle for precise intradermal delivery. Aspiration must be performed before every injection.
Layered Injection & CPM Tissue Integration
Belotero CPM gel is delivered in precise micro-volumes using either micro-droplet or retrograde linear threading technique, matched to the planned tissue depth. In the most superficial planes, micro-droplet placement follows the path of each fine line; at deeper levels, retrograde linear release deposits product just above the periosteum. After every 0.05–0.1 ml injected, the physician immediately massages the area with fingertip pressure to achieve seamless integration of the monophasic gel within the dermis. The full session, including anaesthesia time, takes 30–60 minutes.
Immediate results + stable at 14 days + 6–12 months duration
End of Injection Immediately visible results, However, due to the hydrophilic nature of HA, 10–20% swelling is expected within the first 3–7 days. Belotero® typically produces less swelling than particle-type HA products, owing to its single-phase CPM structure.True stable results achieved by day 14 our clinical expertise on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. The HA is then gradually broken down by hyaluronidase within the tissue, while continuing to stimulate collagen regeneration throughout. Duration varies by product and treatment area: Soft 6–9 months · Balance 6–12 months · Intense / Volume 12 months · Revive 6–9 months.
Tyndall Effect & Vascular Occlusion Prevention
Belotero Its distinctive advantage is that CPM gel can be injected into the most superficial dermis without No Tyndall blue discolouration, However, any superficial injection still requires strict adherence to anatomical tissue planes. Belotero has an excellent safety profile,Vascular occlusion This remains an inherent risk of all HA fillers (< 0.05%). Our physician minimises this risk through three layers of protection: pre-procedure screening, anatomical avoidance of danger zones, and an on-site Hylenex emergency protocol.
Skin thickness assessment
Caliper Measuring dermal thickness + Lemperle wrinkle grading · Superficial layers: Soft / Balance · Deeper layers: Intense / Volume · Mismatching products to depth is strictly contraindicated
Anatomical vascular avoidance
Vascular mapping assessed before each injection · High-risk zones (nose, tear trough, glabella) prioritize blunt cannula + aspiration test + slow, low-pressure technique · Superficial layers treated with 30–32 G sharp needle microdroplet delivery
Hylenex Emergency protocol
Hyaluronidase (Hylenex 150 U/ml) is stocked on-site at all times · CPM monophasic gel responds readily to Hylenex · Immediate dissolution is possible within the 4-hour critical window for vascular occlusion
Am I a Candidate for Belotero Filler?
You may complete a self-assessment before your consultation, but suitability is ultimately determined by our physician through a combination of anatomical evaluation, medical history review, and prior filler history. Belotero CPM is particularly well suited for those seeking“Seamless superficial fine line filling” patients.
You may be a good candidate if…
- Superficial under-eye lines / periorbital fine lines (extremely thin skin · high-risk anatomy for Tyndall effect)
- Perioral barcode lines / smoker’s lines / vertical fine lines (for those seeking correction without a heavy, overfilled appearance)
- Have Nasolabial folds Seeking superficial refinement rather than deep volumization
- Subtle nasal base depression · Insufficient upper lip support
- “Seeking truly invisible correction” seamless, trace-free “result · Concerned about whether others can tell they’ve had a treatment
- Previous Tyndall-effect bluing from another HA filler · Seeking correction or a product switch
- Dry, rough skin texture · Seeking hydration-based bio-remodelling (Revive Skinbooster)
- Maintenance “At least 21 years of age, in good general health, with realistic expectations for natural-looking results and short-to-medium duration maintenance
Treatment is not recommended if any of the following apply…
- Pregnancy or breastfeeding
- Known allergy to hyaluronic acid or lidocaine (or any lidocaine-based anaesthetic)
- Autoimmune skin conditions (lupus erythematosus / scleroderma)
- Active infection at the injection site / active herpes simplex outbreak
- Recent injection of incompatible non-HA fillers in the same area (PMMA / silicone oil / autologous fat)
- Keloid tendency or abnormal scarring history
- Seeking significant volume or deep structural support (consider Juvéderm Voluma/ Restylane Lyft)
- “Those expecting a completely static or permanent result (HA fillers are reversible and temporary)
Treatment Area × Belotero® Product Selection × our physician’s Protocol
Different depths of fine lines require different densities of Belotero CPM gel — this is the core rationale behind Belotero’s five-product lineup:
| Area / Fine Lines | Preferred product | Layer / Depth | Typical Volume |
|---|---|---|---|
| Superficial periorbital lines / under-eye fine lines | Belotero Soft | Most superficial dermis (0.5–1.5 mm) | 0.5-1 ml |
| Perioral bar code lines / smoker’s lines / vertical lip lines | Belotero Balance | Mid-dermis | 1 ml |
| Nasolabial folds / corner of mouth lines | Belotero Balance / Intense | Deep dermis | 1 ml / side |
| Lip volumizing / deep lip lines | Belotero Intense | Submucosal lip layer / deep dermis | 1 ml |
| Nasal base / upper lip support | Belotero Intense | Supraperiosteal / deep layer | 0.5-1 ml |
| Deep support for the cheekbone / jawline | Belotero Volume | Supraperiosteal | 1-2 ml / side |
| Skin hydration / bio-remodelling | Belotero Revive | Multi-point micro-droplet delivery into the mid-dermis | 1 ml × 2-3 sessions |
Belotero® Treatment Planning in Nanjing
Our treatment plans are designed to be safe, predictable, and aligned with your facial anatomy and aesthetic goals. Every plan is personally designed and performed by our physician — never delegated to a technician.
Initial consultation and skin thickness assessment
Free 30-Minute Consultation · MD Codes anatomical analysis + Lemperle wrinkle grading + caliper dermal thickness assessment · Medical history, current medications, and prior filler history review · Clinical photography on file.
CPM Product selection and dosage planning
Our physician selects from Soft / Balance / Intense / Volume / Revive based on wrinkle depth · Transparent pricing confirmed before treatment · Complex cases may involve layered, multi-product combination use.
14 Day follow-up · Assessment of stable results
A follow-up assessment is scheduled 14 days post-treatment to evaluate the true result once swelling has resolved. Any asymmetry or under-correction can be refined with a small touch-up at that visit. CPM monophasic gel reaches full tissue integration within 14 days, making this the optimal time for assessment.
6-12 month maintenance treatment
Touch-up sessions are scheduled according to each product’s metabolic timeline: Soft / Revive 6–9 months · Balance 6–12 months · Intense / Volume 12 months · ensuring continuous skin hydration and collagen stimulation.
Typical treatment timeline
Belotero This is an immediately visible, periodically maintained treatment. Below is a typical timeline from first injection to a stable result:
| Timeline | Content |
|---|---|
| Day 0 | Free 30-Minute Consultation · Anatomical assessment + skin thickness measurement + product selection + personalized quote |
| Day of injection | 30-60 minute procedure (including topical anesthetic wait time) · Walk in, walk out |
| D1-D3 | Mild swelling (CPM monophasic gel produces minimal swelling) · Possible pinpoint bruising at injection sites · Apply cold compress · Avoid heat exposure |
| D7-D14 | Swelling resolved · CPM fully integrated with tissue · 14-day follow-up assessment |
| Months 6–9 | Soft / Revive Consider a top-up with superficial-layer products such as |
| Months 9–12 | Balance / Intense / Volume touch-up with a deeper-plane product |
The specific volume, product selection, and treatment intervals are customized by our physician following your consultation, based on the area treated, your metabolic rate, and your aesthetic goals.
Belotero® Indications Treatable with Belotero
Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. A standout in the HA filler family for superficial fine-line correction, it offers 5 product lines covering a complete density gradient from the ultra-superficial dermis (Soft) to deep periosteal support (Volume). Its CPM monophasic technology makes seamless, trace-free filling possible.
Superficial periorbital lines / under-eye fine lines
The lower eyelid skin is extremely thin (< 0.8 mm), making it one of the highest-risk zones for Tyndall-effect discoloration. Belotero Soft CPM gel can be placed in the most superficial dermal layer without light scattering, smoothing fine lines while leaving no palpable or visible filler.
Soft 0.5-1 ml · Duration 6–9 months
Perioral barcode lines / smoker’s lines
Formed by chronic contraction of the orbicularis oris muscle combined with photoageing-related Vertical fine lines our clinical expertise on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. Belotero Balance Retrograde injection is performed along each line at the mid-dermal level to smooth the perioral area, combined with micro-dose Botox® for enhanced results.
Balance 1 ml · Results last 6–12 months
Nasolabial folds
Belotero Balance This is the HA filler specifically NMPA-registered in 2011 for the treatment of nasolabial folds. The CPM gel moves naturally with facial expressions, and results are further enhanced when combined with Botox® for a subtle lifting effect.
Balance 1 ml / per side · Duration 6–12 months
Lip volumising / lip contouring
Belotero Intense Medium-density CPM is suitable for Lip refinement, Precise injection along the vermilion border and Cupid’s bow — naturally fuller lips with no stiffness.
Intense 1 ml · Duration: 9–12 months
Superficial tear trough correction
The tear trough is an anatomically thin-skinned area where most HA fillers carry a Tyndall risk. Belotero Soft / Balance CPM gel can be safely placed at the superficial tear trough level, while deep cannula injection addresses the underlying shadow for a complete correction.
Soft / Balance 0.5-1 ml · Duration 9 months
Nasal base depression / upper lip support
Bony resorption at the pyriform aperture and insufficient upper lip support are the true anatomical origins of nasolabial folds. Belotero® Intense injected at the supraperiosteal level improves the nasal base, indirectly softening the upper segment of nasolabial folds — avoiding direct volume overfilling.
Intense 0.5-1 ml · Duration: 12 months
Deep support for the cheekbone / jawline
Belotero Volume It is the highest-density CPM gel in the five-product lineup, designed for supraperiosteal injection to support the zygomatic area and jawline. Combined with Soft / Balance for superficial refinement, it forms a complete rejuvenation plan.
Volume 1-2 ml / per side · Duration ~12 months
Skin booster / biological skin remodeling
Belotero Revive contains Glycine + L-proline injectable Skinbooster, delivered via multi-point micro-droplet injections into the mid-dermis · Improves skin dryness, roughness, enlarged pores, and dull complexion · Does not alter facial contour.
Revive 1 ml × 2-3 session(s) · Results last 6–9 months
Belotero Product Line × Indications × Density Reference Table
| Product | Primary indications | Density / injection depth | Maintenance |
|---|---|---|---|
| Balance | Nasolabial folds / perioral area (NMPA-registered) | Medium density · Mid-to-deep dermis | 6-12 months |
| Soft | Periorbital / perioral fine lines / smoker’s lines | Lowest density · Ultra-superficial dermis (0.5–1.5 mm depth) | 6-9 months |
| Intense | Lips / deep folds / nasal base | Medium-to-high density · Deep dermis / submucosal layer | 9-12 months |
| Volume | Zygomatic area / jawline / deep structural support | Highest density · Supraperiosteal plane | 12 months |
| Revive | Skin booster / bio-remodelling | Low cross-linking + amino acids · Intradermal micro-droplet | 6-9 months |
Pre-Procedure Instructions · Treatment Process · Post-Procedure Care
“Following the care protocol is what transforms your Belotero® treatment from” possible bruising and noticeable swelling “into” natural-looking results that last.“Please read carefully and feel free to ask our physician any questions.
Pre-Procedure Preparation (1 week before injection)
- Discontinue aspirin, ibuprofen, NSAIDs, and blood-thinning medications 1 week prior (if medically permitted)
- Discontinue fish oil, vitamin E, ginkgo, garlic supplements, and red wine 1 week prior
- No alcohol for 24 hours before injection · Avoid vasodilation, which increases bruising risk
- Disclose all current medications, allergy history, autoimmune conditions, and prior filler history (including non-HA fillers)
- Arrive for your appointment on injection day with a clean face and no makeup
- If you have an important event (wedding / photo shoot), schedule your treatment at least 2 weeks in advance to allow adequate time for swelling to resolve
- Not suitable during pregnancy, breastfeeding, or active illness with fever
During the Procedure (30–60 minutes)
- Skin disinfection + MD Codes mapping + Lemperle wrinkle grading markings
- Topical lidocaine cream applied for 20–30 minutes (select Belotero® formulations also contain 0.3% lidocaine)
- Superficial injections use a 30–32 G sharp needle with micro-droplet technique · Deeper injections use a 27 G blunt cannula
- Slow, low-pressure retrograde / micro-droplet injection technique · Aspiration test before each injection
- Real-time massage and contouring · Promotes seamless integration of CPM monophasic gel with dermal tissue
- Apply a cold compress for 5–10 minutes after injection to reduce swelling
- The procedure is performed with the patient seated or semi-reclined · Fully awake and in communication throughout
Post-Procedure Care (24 Hours + 14 Days)
- 24 Within hours: No makeup, do not rub the injection site, avoid sleeping face-down
- 48 Within hours: Avoid strenuous exercise, saunas, hot springs, and hot yoga
- Within 1 week: Avoid facial massage, beauty treatments, and deep-tissue spa services
- Within 2 weeks: Avoid air travel (if unavoidable, inform your physician)
- Cold compresses help reduce swelling · Arnica cream or gel may help accelerate bruise resolution
- 14 Follow-up assessment scheduled after [X] days · Minor refinements performed once results have stabilised (if needed)
- Daily SPF 50+ sun protection slows HA degradation · Stay well-hydrated to support HA water absorption
- If you experience severe pain, skin blanching or turning purple/dark, or any changes in vision, contact the clinic immediately (signs of vascular occlusion)
D0–D30 Complete Recovery Timeline
| Duration | What clients should do · and what to avoid |
|---|---|
| D0 (on the day of injection) | Immediately visible results · Cold compress No Makeup No Avoid strenuous exercise · Do not sleep face-down for 24 hours |
| D1-D3 | Mild swelling (CPM monophasic formulation typically causes minimal swelling) · Possible pinpoint bruising · Continue cold compress · Avoid saunas and hot yoga |
| D4-D7 | Swelling gradually subsides · Bruising transitions to a yellow-brown stage · Light makeup may be resumed |
| D8-D14 | CPM Full tissue integration achieved · Return visit on day 14 for reassessment · Touch-up if needed |
| D15-D30 | Stable phase · Final results visible · Comparison photos taken for documentation · Normal daily activities can resume |
Belotero® Advantages of Belotero Filler
The filler defines the possibilities; the physician defines the direction — but a superior product still gives the physician more options. Belotero CPM monophasic multi-density technology holds a unique position for superficial fine line correction and seamless volumizing.
No Tyndall blue discolouration
The only HA filler that can be placed in the most superficial dermis without producing Tyndall-effect bluing.
CPM Monophasic multi-density
Secondary cross-linking overlay · Controlled density gradient · Uniform refractive index.
Seamless tissue integration
Tissue integration · The texture is virtually indistinguishable from surrounding native tissue.
Specialization in superficial fine line correction
First choice for seamless periorbital, perioral, and smoker’s line correction.
Minimal swelling
Monophasic gel maintains stable water content · Less post-injection swelling compared to biphasic HA fillers.
Reversibility
Hylenex Fully reversible at any time · CPM gel responds readily to enzymatic dissolution.
NMPA-registered
Balance 2011 Nasolabial fold-approved · Swiss origin.
Revive Amino acid skin booster
Contains glycine + proline · Skin bioremodeling.
Belotero® vs Juvéderm® / Restylane® / Teosyal® Full comparison
| Brand | Manufacturer | Cross-linking technology | Clinical characteristics | Maintenance |
|---|---|---|---|---|
| Belotero® | Merz Aesthetics | CPM Monophasic multi-density | Targets superficial fine lines · No Tyndall effect · Highest degree of tissue integration | 6-12 months |
| Juvéderm® | Allergan / AbbVie | Vycross / Hylacross | Soft cohesive full product range · Voluma for cheekbones · Longer-lasting results | 12-24 months |
| Restylane® | Galderma | NASHA / OBT (XpresHAn) | Particulate precision support · Eyelight preferred for tear troughs | 6-18 months |
| Teosyal® | Teoxane (Switzerland) | Preserved Network | Minimal swelling · RHA series suitable for dynamic facial areas | 9-18 months |
Note: Our physician selects products based on your treatment area, anatomy, and budget. Some cases involve multi-brand combination therapy — for example, Voluma for deep cheekbone support combined with Belotero Soft for superficial under-eye fine line refinement. See the full HA filler brand comparison guide for details.
Why Trust Luowei Medical Aesthetics Clinic for Belotero Treatments in Nanjing?
Google’s E-E-A-T framework evaluates medical content across four dimensions. The following credentials substantiate every claim made on this page.
Real-world clinical experience
- Multiple Tyndall blue correction cases from other clinics
- Facial anatomy + MD Codes + Lemperle wrinkle grading protocol
- CPM Clinical experience with the complete single-phase, multi-density product line
Industry Credentials
- Merz Aesthetics collaborative physician (Belotero / Radiesse / Xeomin (manufacturer)
- Galderma / Restylane collaborative physician
Transparent and verifiable
- Written informed consent form signed before each injection session
- Belotero Products sourced from Merz’s domestic cold-chain supply
- Hylenex Hyaluronidase emergency kit on site at all times
Belotero® is not an “all-purpose HA” — it is the physics-based answer for superficial fine lines
Our clinical expertise on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. Belotero “Using Volume under the eyes for fine lines = overfilling; injecting Soft deep into the cheekbone = insufficient support; injecting any particle-type HA into the extremely thin skin of the infraorbital area = Tyndall blue discolouration. The value of Belotero® lies not in” doing everything “nadequate support; placing any particulate HA in the thin-skinned infraorbital area = Tyndall blue. The value of Belotero lies not in” doing everything, “but in:” Seamless superficial fine line filling “ our clinical expertise on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. CPM Cohesive polydensified matrix cross-linking technology is not a marketing term — it is a physics-based patent developed over 20+ years by Anteis SA, a Swiss laboratory under Merz Aesthetics.
Our physician serves as Merz Aesthetics collaborative physician, our clinical expertise on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane. Belotero HA — but realizing its full value requires the physician to accurately assessHis clinical insights on Belotero® application in Asian faces and Tyndall correction have become a reference among peers. Belotero® is the only CPM-technology HA filler NMPA-registered specifically for nasolabial folds (2011) — but realizing its full value requires the physician to accurately assess which fine lines truly belong in the superficial plane.
Belotero® Filler Pricing & Payment — Nanjing
Pricing by syringe Pricing is per syringe and varies by product line, volume, and whether combination therapy is used.Personalized pricing provided by our physician following a free 30-minute consultation.
Belotero Priced per syringe · 1 ml (Soft / Balance / Intense / Revive) / 2 ml (Volume)
Periorbital / perioral fine lines 1 syringe · Nasolabial folds 1–2 syringes · Nasal base 0.5–1 syringe · Skin booster 1 syringe × 2–3 sessions
- Payment is made at the clinic, after the consultation and before treatment begins
- Nothing is paid in advance, and no deposit is required to hold an appointment
- Cosmetic treatment is a self-pay item and is not covered by public medical insurance in China
- All new clients receive a complimentary 30-minute Free Consultation & Assessment
Common Risks · Contraindications · Vascular Occlusion Prevention
Transparency in medical aesthetics is itself a marker of expertise and trustworthiness. We openly disclose all possible reactions, serious risks, contraindications, and absolute precautions so you are fully informed before your consultation. Our physician reviews each item with you individually before every injection session.
Common reactions (typically occurring in the short term after injection)
- Injection-site redness and swelling / small needle marks (1-3 hours to resolve · Superficial 30–32 G sharp needle entry points are minimal in size)
- Temporary swelling (CPM Monophasic gel produces minimal swelling · Peak swelling on Day 1–2 · Fully resolved within 5–10 days)
- Bruising (Approximately 5–15% likelihood · Resolves in 5–10 days · Arnica may help speed resolution)
- Tenderness at injection sites (24-48 hours · Similar to mild muscle soreness)
- Transient skin blanching following superficial injection (Capillary response · Resolves within hours · Not a sign of vascular occlusion)
- Minor asymmetry (Normal during the resolution of swelling · Follow-up assessment at 14 days)
Serious Risks (rare but must be disclosed)
- Vascular Occlusion— Extremely rare (< 0.05%) but the most serious complication of HA filler · Presents as severe pain, skin blanching / purple-black discoloration, livedo reticularis · Within the 4-hour golden window, Hylenex hyaluronidase can dissolve the filler (CPM monophasic gel is highly enzyme-responsive) · Severe cases may result in skin necrosis or vision loss
- Tyndall effect (bluish light transmission)— Belotero CPM The monophasic gel’s refractive index matches skin tissue, making the Tyndall risk significantly lower than with other HA fillers · However, any HA placed too superficially carries a theoretical risk · Hylenex can provide immediate correction if needed
- Foreign body granuloma— Rare · Typically associated with biofilm infection · Requires combined antibiotic therapy and Hylenex dissolution
- Allergic reaction— Extremely rare · Lidocaine-containing series requires screening for local anesthetic allergy history
- Late-onset nodules— Rare · May appear months after injection · Often immune-mediated · Reversible with dissolution
- Infection— Rare · Preventable with strict aseptic technique · Relatively higher incidence in the metabolically active perioral region
Absolute contraindications (treatment not performed)
- Pregnancy / breastfeeding
- Known allergy to hyaluronic acid or lidocaine (or any lidocaine-based anaesthetic)
- Autoimmune conditions affecting the skin (lupus erythematosus / scleroderma / sarcoidosis)
- Active infection at the injection site / active herpes simplex outbreak
- Recent injection of incompatible non-HA fillers in the same area (PMMA / silicone oil / autologous fat)
- Keloid tendency or abnormal scarring history
- Active fever / flu
- Minors (< 21 years of age, except for specific medical indications)
Safety Protocols Mandated by our physician
- Every patient undergoes anatomical assessment, skin thickness measurement, and a review of medical history, current medications, and prior filler history (including non-HA fillers) before injection
- Written informed consent form signed before each injection session
- All Belotero products are sourced from Merz’s domestic cold chain · Maintained at 2–25°C throughout
- All Belotero® injections are performed personally by our physician — never delegated to technicians
- Superficial injections use a 30–32 G sharp needle with micro-droplet technique · Deep layers and high-risk zones use a 27 G blunt cannula
- Available on-site at all times Hylenex Hyaluronidase (150 U/ml) Vascular occlusion: 4-hour golden rescue window
- Aspiration test before each injection · Slow, low-pressure injection technique · Micro-droplet / retrograde linear micro-bolus delivery
- Follow-up appointment 14 days post-injection · Clinical photography on file · Assessment for any touch-up needs
Where the medical claims on this page come from
Everything above about Belotero® rests on published evidence rather than on our own word. The sources below are the ones behind those statements: peer-reviewed papers indexed in PubMed, and guidance written for patients by dermatology academies and national health services. Read them before you decide — and bring any of them to your consultation.
- Peer-reviewedHyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies
- Peer-reviewedHyaluronidase for Dermal Filler Complications: Review of Applications and Dosage Recommendations
- Peer-reviewedBotulinum toxin type A for facial wrinkles
- Patient guidanceDermal fillers: Overview
- Patient guidanceBotulinum toxin: Overview
- Patient guidanceNeedle-free filler risks: What you should know
What these references can and cannot tell you. They describe what is known about the treatment itself — how well it tends to work, how long results last, and what can go wrong. They are not an assessment of this clinic, and no published study can tell you whether it suits your skin type, anatomy, or medical history. That judgement comes from the physician who examines you in person, and it may well be “not this one”.